Acute stress exposure preceding transient global brain ischemia exacerbates the decrease in cortical remodeling potential in the rat retrosplenial cortex
| Autor: | Kaoru Sakatani, Nobuo Kutsuna, Yoichi Katayama, Takamitsu Yamamoto, Atsuo Yoshino, Takashi Eriguchi, Akiko Yamashita, Hideki Oshima, Takeshi Suma |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Doublecortin Domain Proteins
Male Cingulate cortex medicine.medical_specialty Doublecortin Protein Gyrus Cinguli Calbindin Brain Ischemia Rats Sprague-Dawley Brain ischemia Retrosplenial cortex Internal medicine medicine Animals Swimming Anterior cingulate cortex Cerebral Cortex Neuronal Plasticity biology business.industry General Neuroscience Neuropeptides General Medicine medicine.disease Rats Doublecortin medicine.anatomical_structure Endocrinology Anesthesia biology.protein GABAergic business Microtubule-Associated Proteins Stress Psychological Parvalbumin |
| Zdroj: | Neuroscience Research. 78:65-71 |
| ISSN: | 0168-0102 |
| Popis: | Doublecortin (DCX)-immunoreactive (-ir) cells are candidates that play key roles in adult cortical remodeling. We have previously reported that DCX-ir cells decrease after stress exposure or global brain ischemia (GBI) in the cingulate cortex (Cg) of rats. Herein, we investigate whether the decrease in DCX-ir cells is exacerbated after GBI due to acute stress exposure preconditioning. Twenty rats were divided into 3 groups: acute stress exposure before GBI (Group P), non-stress exposure before GBI (Group G), and controls (Group C). Acute stress or GBI was induced by a forced swim paradigm or by transient bilateral common carotid artery occlusion, respectively. DCX-ir cells were investigated in the anterior cingulate cortex (ACC) and retrosplenial cortex (RS). The number of DCX-ir cells per unit area (mm(2)) decreased after GBI with or without stress preconditioning in the ACC and in the RS (ANOVA followed by a Tukey-type test, P |
| Databáze: | OpenAIRE |
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