Impact of Short Term Consumption of Diets High in Either Non-Starch Polysaccharides or Resistant Starch in Comparison with Moderate Weight Loss on Indices of Insulin Sensitivity in Subjects with Metabolic Syndrome
| Autor: | David Bremner, Gerald E. Lobley, Grietje Holtrop, A. Graham Calder, Eric Milne, Alexandra M. Johnstone |
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| Rok vydání: | 2013 |
| Předmět: |
Blood Glucose
Male resistant starch Minimal Models Starch medicine.medical_treatment stable isotope kinetics chemistry.chemical_compound Weight loss Homeostasis Insulin Resistant starch Cross-Over Studies Nutrition and Dietetics C-Peptide Fasting Carbohydrate Metabolism Dietary Proteins medicine.symptom lcsh:Nutrition. Foods and food supply medicine.medical_specialty food.ingredient Diet Reducing lcsh:TX341-641 Biology Carbohydrate metabolism Models Biological Article metabolic syndrome Animal science Insulin resistance food insulin sensitivity non-starch polysaccharides weight loss Leucine Polysaccharides Internal medicine medicine Humans Obesity medicine.disease Endocrinology chemistry Insulin Resistance Metabolic syndrome Energy Intake Energy Metabolism Food Science |
| Zdroj: | Nutrients, Vol 5, Iss 6, Pp 2144-2172 (2013) Nutrients; Volume 5; Issue 6; Pages: 2144-2172 Nutrients |
| ISSN: | 2072-6643 |
| DOI: | 10.3390/nu5062144 |
| Popis: | This study investigated if additional non-starch polysaccharide (NSP) or resistant starch (RS), above that currently recommended, leads to better improvement in insulin sensitivity (IS) than observed with modest weight loss (WL). Obese male volunteers (n = 14) were given an energy-maintenance (M) diet containing 27 g NSP and 5 g RS daily for one week. They then received, in a cross-over design, energy-maintenance intakes of either an NSP-enriched diet (42 g NSP, 2.5 g RS) or an RS-enriched diet (16 g NSP, 25 g RS), each for three weeks. Finally, a high protein (30% calories) WL diet was provided at 8 MJ/day for three weeks. During each dietary intervention, endogenous glucose production (EGP) and IS were assessed. Fasting glycaemia was unaltered by diet, but plasma insulin and C-peptide both decreased with the WL diet (p < 0.001), as did EGP (−11%, p = 0.006). Homeostatis model assessment of insulin resistance improved following both WL (p < 0.001) and RS (p < 0.05) diets. Peripheral tissue IS improved only with WL (57%–83%, p < 0.005). Inclusion of additional RS or NSP above amounts currently recommended resulted in little or no improvement in glycaemic control, whereas moderate WL (approximately 3 kg fat) improved IS. |
| Databáze: | OpenAIRE |
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