Recent development of AAV-based gene therapies for inner ear disorders
| Autor: | Yiling Wu, Qiuxiang Yang, Yiyang Lan, Bing Su, Xiaoyi Liu, Chao-Po Lin, Junzi Ke, Yunfeng Wang, Guisheng Zhong, Yong Tao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Hearing loss Genetic enhancement Genetic Vectors Review Article Biology Bioinformatics Viral vector 03 medical and health sciences Transduction (genetics) 0302 clinical medicine Genetics medicine Animals Humans Inner ear Hearing Loss Molecular Biology Cochlea Targeted Gene Repair DNA damage and repair Genetic Therapy Dependovirus Targeted gene repair 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Molecular Medicine Animal studies medicine.symptom |
| Zdroj: | Gene Therapy |
| ISSN: | 1476-5462 0969-7128 |
| Popis: | Gene therapy for auditory diseases is gradually maturing. Recent progress in gene therapy treatments for genetic and acquired hearing loss has demonstrated the feasibility in animal models. However, a number of hurdles, such as lack of safe viral vector with high efficiency and specificity, robust deafness large animal models, translating animal studies to clinic etc., still remain to be solved. It is necessary to overcome these challenges in order to effectively recover auditory function in human patients. Here, we review the progress made in our group, especially our efforts to make more effective and cell type-specific viral vectors for targeting cochlea cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink