In vitro culture systems as an alternative for female reproductive toxicology studies
| Autor: | Jamily Bezerra Bruno, Gildas Tetaping Mbemya, Ana Paula Ribeiro Rodrigues, Denise Damasceno Guerreiro, José Ricardo de Figueiredo, L. R. Faustino |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Reproductive toxicology Biology Bioinformatics Cell Line 03 medical and health sciences 0302 clinical medicine Organ Culture Techniques Ovarian Follicle In vivo Reproductive biology Toxicity Tests Animals Humans Daily exposure Reproductive health 030219 obstetrics & reproductive medicine Reproductive function business.industry Reproduction Ovary Cell Biology In vitro 030104 developmental biology Oocytes Female Reproductive toxicity business Developmental Biology |
| Zdroj: | Zygote (Cambridge, England). 27(2) |
| ISSN: | 1469-8730 |
| Popis: | SummaryStudies have shown that daily exposure to different products, whether chemical or natural, can cause irreversible damage to women’s reproductive health. Therefore it is necessary to use tests that evaluate the safety and efficacy of these products. Most reproductive toxicology tests are performedin vivo. However, in recent years, various cell culture methods, including embryonic stem cells and tissues have been developed with the aim of reducing the use of animals in toxicological tests. This is a major advance in the area of toxicology, as these systems have the potential to become a widely used tool compared within vivotests routinely used in reproductive biology and toxicology. The present review describes and highlights data onin vitroculture processes used to evaluate reproductive toxicity as an alternative to traditional methods usingin vivotests. |
| Databáze: | OpenAIRE |
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