Self-Powered Wireless Carbohydrate/Oxygen Sensitive Biodevice Based on Radio Signal Transmission

Autor: Han, Arum, Falk, Magnus, Alcalde, Miguel, Bartlett, Philip N., De Lacey, Antonio L., Gorton, Lo, Gutierrez-Sanchez, Cristina, Haddad, Raoudha, Kilburn, Jeremy, Leech, Dónal, Ludwig, Roland, Magner, Edmond, Mate, Diana M., Conghaile, Peter Ó., Ortiz, Roberto, Pita, Marcos, Pöller, Sascha, Ruzgas, Tautgirdas, Salaj-Kosla, Urszula, Schuhmann, Wolfgang, Sebelius, Fredrik, Shao, Minling, Stoica, Leonard, Sygmund, Cristoph, Tilly, Jonas, Toscano, Miguel D., Vivekananthan, Jeevanthi, Wright, Emma, Shleev, Sergey
Přispěvatelé: ERC, European Commission, Novosense AB
Rok vydání: 2014
Předmět:
Bioelectric Energy Sources
Radio Waves
lcsh:Medicine
Biosensing Techniques
02 engineering and technology
Biochemistry
01 natural sciences
laccase
law.invention
carbon naonotubes
implantable biofuel cell
direct electron-transfer
law
Naturvetenskap
Bioenergy
Enzyme Chemistry
lcsh:Science
cellobiose dehydrogenase
Multidisciplinary
Transmitter
Electrical engineering
fuel-cells
021001 nanoscience & nanotechnology
Capacitor
Engineering and Technology
Alternative Energy
Natural Sciences
0210 nano-technology
devices
Research Article
Biotechnology
Cellobiose dehydrogenase
Materials science
glucose biosensors
Carbohydrates
Biophysics
Bioenergetics
USB
010402 general chemistry
Wireless
logic
business.industry
Amplifier
lcsh:R
Biology and Life Sciences
0104 chemical sciences
Oxygen
Energy and Power
Bionanotechnology
Enzymology
Biocatalysis
lcsh:Q
business
Energy harvesting
Biosensor
Zdroj: PLoS ONE, Vol 9, Iss 10, p e109104 (2014)
Digital.CSIC. Repositorio Institucional del CSIC
instname
PLoS ONE
ISSN: 1932-6203
Popis: Falk, Magnus et al.
Here for the first time, we detail self-contained (wireless and self-powered) biodevices with wireless signal transmission. Specifically, we demonstrate the operation of self-sustained carbohydrate and oxygen sensitive biodevices, consisting of a wireless electronic unit, radio transmitter and separate sensing bioelectrodes, supplied with electrical energy from a combined multi-enzyme fuel cell generating sufficient current at required voltage to power the electronics. A carbohydrate/oxygen enzymatic fuel cell was assembled by comparing the performance of a range of different bioelectrodes followed by selection of the most suitable, stable combination. Carbohydrates (viz. lactose for the demonstration) and oxygen were also chosen as bioanalytes, being important biomarkers, to demonstrate the operation of the self-contained biosensing device, employing enzyme-modified bioelectrodes to enable the actual sensing. A wireless electronic unit, consisting of a micropotentiostat, an energy harvesting module (voltage amplifier together with a capacitor), and a radio microchip, were designed to enable the biofuel cell to be used as a power supply for managing the sensing devices and for wireless data transmission. The electronic system used required current and voltages greater than 44 µA and 0.57 V, respectively to operate; which the biofuel cell was capable of providing, when placed in a carbohydrate and oxygen containing buffer. In addition, a USB based receiver and computer software were employed for proof-of concept tests of the developed biodevices. Operation of bench-top prototypes was demonstrated in buffers containing different concentrations of the analytes, showcasing that the variation in response of both carbohydrate and oxygen biosensors could be monitored wirelessly in real-time as analyte concentrations in buffers were changed, using only an enzymatic fuel cell as a power supply.
The research was undertaken as part of a “3D-nanobiodevice” consortium (www.mah.se/3dnanobiodevice) organized and funded under the EU FP7 NMP program. Co-authors Fredrik Sebelius and Jonas Tilly are employed by Novosense AB. Novosense AB provided support in the form of salaries for authors Fredrik Sebelius and Jonas Tilly, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Databáze: OpenAIRE
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