Effects of non-steroidal anti-inflammatory drugs on canine neutrophil chemotaxis
| Autor: | Thomsen Mk, Strøm H |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Flunixin
Neutrophils Indomethacin Pharmacology Leukotriene B4 chemistry.chemical_compound Dogs Phenylbutazone medicine Animals Masoprocol IC50 General Veterinary Dose-Response Relationship Drug Anti-Inflammatory Agents Non-Steroidal Chemotaxis In vitro Clonixin Nordihydroguaiaretic acid Neutrophil chemotaxis Chemotaxis Leukocyte chemistry Immunology Ex vivo medicine.drug |
| Zdroj: | Journal of veterinary pharmacology and therapeutics. 13(2) |
| ISSN: | 0140-7783 |
| Popis: | Strom, H. & Krogsgaard Thomsen, M. Effects of non-steroidal anti-inflammatory drugs on canine neutrophil chemotaxis. J. vet. Pharmacol. Therap. 13, 186–191. Non-steroidal anti-inflammatory drugs exhibit differences in their ability to suppress polymorphonuclear leucocyte (PMN) functions in different species. The present study investigated the in-vitro and ex-vivo effects of phenylbutazone and flunixin on leukotriene-B4-directed migration of canine PMN. Furthermore, in-vitro comparison was made to indomethacin and the 5-lipoxygenase inhibitor, nordihydroguaiaretic acid (NDGA). In vitro, flunixin and NDGA were the most potent inhibitors, with IC50s of 13 and 7 μmol/l, respectively. Phenylbutazone had an IC50 of 42 μmol/l whereas indomethacin did not achieve 50% inhibition at concentrations less than 100 μmol/l. Ex vivo, flunixin almost completely abolished the LTB4 response at 1h, and still possessed significant inhibitory activity 24 h after a dosage of 1mg/kg i.v. Phenylbutazone was less active ex vivo but did suppress chemotaxis by 23% (P |
| Databáze: | OpenAIRE |
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