Three Novel Xanthones from Garcinia paucinervis and Their Anti-TMV Activity
| Autor: | Zhen-Yuan Xia, Wei Zhao, Guang-Hui Kong, Xiu-Ping Lu, Qiu-Fen Hu, Xue-Mei Gao, Yu-Ping Wu |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Xanthones Plant composition Garcinia paucinervis Pharmaceutical Science Antiviral Agents Mass Spectrometry Article Analytical Chemistry lcsh:QD241-441 lcsh:Organic chemistry Drug Discovery Tobacco mosaic virus Physical and Theoretical Chemistry Molecular Structure biology Chemistry anti-tobacco mosaic virus Organic Chemistry Nuclear magnetic resonance spectroscopy biology.organism_classification Tobacco Mosaic Virus Phytochemical Chemistry (miscellaneous) xanthones Molecular Medicine Garcinia Chemical control |
| Zdroj: | Molecules; Volume 18; Issue 8; Pages: 9663-9669 Molecules Molecules, Vol 18, Iss 8, Pp 9663-9669 (2013) |
| ISSN: | 1420-3049 |
| Popis: | Phytochemical investigations of the leaves of Garcinia paucinervis resulted in the isolation of three new xanthones 1–3 and five known analogues 4–8. Structural elucidations of 1–3 were performed by spectral methods such as 1D and 2D (HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution mass spectrometry. Compounds 1–3 showed anti-TMV activities, with inhibition rates above 20%, especially for 1, which had a lower IC50 value of 21.4 µM. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|