Comparison of HE 4, CA 125, ROMA score and ultrasound score in the differential diagnosis of ovarian masses
| Autor: | Canan Yilmaz, Neslihan Bukan, M. Anıl Onan, Mehmet Erdem, Koray Aslan |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Turkey Risk of malignancy Single Center Sensitivity and Specificity Diagnosis Differential 03 medical and health sciences 0302 clinical medicine WAP Four-Disulfide Core Domain Protein 2 Medicine Humans Prospective Studies Prospective cohort study Aged Ultrasonography Ovarian Neoplasms 030219 obstetrics & reproductive medicine Receiver operating characteristic business.industry Ultrasound Obstetrics and Gynecology Middle Aged medicine.disease Cancer antigen Reproductive Medicine ROC Curve 030220 oncology & carcinogenesis CA-125 Antigen Female Radiology Differential diagnosis Menopause business Ovarian cancer Algorithms |
| Zdroj: | Journal of gynecology obstetrics and human reproduction. 49(5) |
| ISSN: | 2468-7847 |
| Popis: | To compare the value of ultrasonography (USG) score, cancer antigen 125 (CA 125), human epididymis protein 4 (HE 4) and risk of malignancy algorithm (ROMA) in differential diagnosis ovarian masses.This prospective study was conducted between May 2012 and September 2013 in a single center. Eighty-four women who had an ovarian mass on imaging and underwent surgery were included. The diagnostic performances of CA 125, HE 4, ROMA score and USG score for ovarian cancer were analyzed.There were 65 (77.3 %) women with benign ovarian tumors and 19 (22.7 %) women with malignant ovarian tumors. According to receiver operating characteristic (ROC) analysis; area under curve (AUC) was 0.874 for the USG score (p0.001), 0.794 for the CA 125 (p0.001), 0.9 for the HE 4 (p0.001), and 0.893 for the ROMA (p0.001). The USG score ≥ 3 had a sensitivity of 68.4 % and specificity of 90.7 %.The CA 125 ≥ 35 IU/l, had a sensitivity of 84.2 %, specificity of 49.2 %, the HE 4 ≥ 150 pM, had a sensitivity of 84.2 %, specificity of 98.4 % and the ROMA score had a sensitivity of 84.2 %, specificity of 75.3 % CONCLUSION: The HE 4 had higher accuracy than ROMA score, USG score and CA 125, in predicting ovarian cancer. Besides, the USG score was a simple and achievable method with acceptable performance. |
| Databáze: | OpenAIRE |
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