BEL-2 an extended-spectrum beta-lactamase with increased activity toward expanded-spectrum cephalosporins in Pseudomonas aeruginosa
| Autor: | Gian Maria Rossolini, Laurent Poirel, Filomena De Luca, Patrice Nordmann, Annemie Verlinde, Louis Ide, Jean Denis Docquier |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
medicine.drug_class
medicine.medical_treatment Cephalosporin Microbial Sensitivity Tests medicine.disease_cause beta-Lactamases Microbiology 03 medical and health sciences Belgium Mechanisms of Resistance medicine Escherichia coli Humans Pharmacology (medical) Pseudomonas Infections 030304 developmental biology Antibacterial agent Cephalosporinase Pharmacology 0303 health sciences Cross Infection biology 030306 microbiology Pseudomonas aeruginosa biology.organism_classification Cephalosporins Kinetics Infectious Diseases Genes Bacterial Pseudomonadales Beta-lactamase Bacteria Pseudomonadaceae |
| Zdroj: | Antimicrobial Agents and Chemotherapy; Vol 54 Antimicrobial Agents and Chemotherapy |
| ISSN: | 0066-4804 |
| DOI: | 10.1128/AAC.00859-09 |
| Popis: | A Pseudomonas aeruginosa isolate recovered in Belgium produced a novel extended-spectrum ß-lactamase, BEL-2, differing from BEL-1 by a single Leu162Phe substitution. That modification significantly altered the kinetic properties of the enzyme, increasing its affinity for expanded-spectrum cephalosporins. The bla BEL-2 gene was identified from a P. aeruginosa isolate clonally related to another bla BEL-1 -positive isolate. |
| Databáze: | OpenAIRE |
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