The genome of the blood fluke Schistosoma mansoni
| Autor: | John P. Overington, Appoliniare Djikeng, Paul McVeigh, Zemin Ning, Gaëlle Blandin, Steven L. Salzberg, Mohammed Sajid, Mario Stanke, Raymond J. Pierce, Richard M.R. Coulson, Mihaela Pertea, Arthur L. Delcher, Hirohisha Hirai, Yong-Hong Gu, Adhemar Zerlotini, Anna V. Protasio, Tim A. Day, Susan T. Mashiyama, Daniela R. Lacerda, Mostafa Zamanian, R. Alan Wilson, Luiza F. Andrade, Alasdair Ivens, Camila D. S. Macedo, Robin Houston, Julian Parkhill, Elodie Ghedin, Najib M. El-Sayed, Gary P. Dillon, Marie-Adèle Rajandream, Wenjie Wu, Daniella Castanheira Bartholomeu, Brian J. Haas, John Gamble, Tina Eyre, Philip T. LoVerde, Jane Rogers, Peter D. Ashton, Conor R. Caffrey, David L. Williams, Martin Aslett, Jennifer R. Wortman, Matthew Berriman, Ricardo DeMarco, Bissan Al-Lazikani, Gustavo C. Cerqueira, Guilherme Oliveira, Yuriko Hirai, Adrian Tivey, David A. Johnston, Owen White, Barclay G. Barrell, Michael A. Quail, Claire M. Fraser-Liggett, Avril Coghlan, Christiane Hertz-Fowler |
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| Rok vydání: | 2009 |
| Předmět: |
ESQUISTOSSOMOSE (TRATAMENTO)
Systems biology Molecular Sequence Data 030231 tropical medicine Lophotrochozoa Genomics Helminth genetics Proteomics Genome Article Host-Parasite Interactions 03 medical and health sciences 0302 clinical medicine Animals Genes Helminth 030304 developmental biology Schistosoma Genetics Genome Helminth 0303 health sciences Multidisciplinary biology Exons Schistosoma mansoni Physical Chromosome Mapping biology.organism_classification Biological Evolution Introns Schistosomiasis mansoni 3. Good health |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Nature |
| Popis: | Schistosoma mansoni is responsible for the neglected tropical disease schistosomiasis that affects 210 million people in 76 countries. We report here analysis of the 363 megabase nuclear genome of the blood fluke. It encodes at least 11,809 genes, with an unusual intron size distribution, and novel families of micro-exon genes that undergo frequent alternate splicing. As the first sequenced flatworm, and a representative of the lophotrochozoa, it offers insights into early events in the evolution of the animals, including the development of a body pattern with bilateral symmetry, and the development of tissues into organs. Our analysis has been informed by the need to find new drug targets. The deficits in lipid metabolism that make schistosomes dependent on the host are revealed, while the identification of membrane receptors, ion channels and more than 300 proteases, provide new insights into the biology of the life cycle and novel targets. Bioinformatics approaches have identified metabolic chokepoints while a chemogenomic screen has pinpointed schistosome proteins for which existing drugs may be active. The information generated provides an invaluable resource for the research community to develop much needed new control tools for the treatment and eradication of this important and neglected disease. |
| Databáze: | OpenAIRE |
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