Neuropathologic Findings of Bromethalin Toxicosis in the Cat
Autor: | D. C. Dorman, James F. Zachary, William B. Buck |
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Rok vydání: | 1992 |
Předmět: |
Male
0301 basic medicine Cerebellum medicine.medical_specialty Ataxia 040301 veterinary sciences 030106 microbiology Central nervous system Cat Diseases Nervous System 0403 veterinary science White matter 03 medical and health sciences chemistry.chemical_compound Internal medicine Glial Fibrillary Acidic Protein medicine Animals Peripheral Nerves Aniline Compounds CATS General Veterinary business.industry Cerebrum Poisoning Brain Rodenticides 04 agricultural and veterinary sciences Anatomy Spinal cord Bromethalin Immunohistochemistry Microscopy Electron medicine.anatomical_structure Endocrinology Spinal Cord chemistry Cats Nervous System Diseases medicine.symptom business Neuroglia |
Zdroj: | Veterinary Pathology. 29:139-144 |
ISSN: | 1544-2217 0300-9858 |
Popis: | Ten random source male domestic shorthair cats, 2 to 6 years old and 3.0–4.4 kg body weight, were each given a single oral dose (1.5 mg/kg) of bromethalin (cat Nos. 1–5) or bait vehicle carrier (cat Nos. 6–10). Bromethalin-dosed cats developed a toxic syndrome characterized by ataxia, focal motor seizures, vocalization, decerebrate posture, decreased conscious proprioception, recumbency, depression, and semicoma. Bromethalin-dosed cats were euthanatized if seizure activity or hindlimb paralysis developed. Survival times were 48 hours (cat No. 1), 89 hours (cat No. 2), 90 hours (cat No. 3), and 97 hours (cat No. 4). Control cats (cat Nos. 6–10) and one bromethalin-dosed cat (cat No. 5) were euthanatized on day 20 after dosing. Spongy change (edema—characterized by the formation of vacuoles in extracellular spaces and myelin lamellae), hypertrophied fibrous astrocytes, and hypertrophied oligodendrocytes were observed in the white matter of the cerebrum, cerebellum, brain stem, spinal cord, and optic nerve of all bromethalin-dosed cats. Spongy change occasionally extended into contiguous cerebellar Purkinje cell layer and cerebral cortical gray matter. The severity of lesions varied among cats but was most pronounced in cat No. 5 (480 hours after dosing). A leukocytic inflammatory response, gitter cell (macrophage) response, or axonal degeneration was not observed in the vacuolated areas. Ultrastructural findings included separation of myelin lamellae at the interperiod lines with the formation of intramyelinic vacuoles (intramyelinic edema), rupture and coalescence of intramyelinic vacuoles into larger extracellular spaces (spongy change), and pronounced cytosolic edema of astrocytes and oligoden-droglial cells. |
Databáze: | OpenAIRE |
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