Sleep Complaints and the 24‐h Melatonin Level in Individuals with Smith–Magenis Syndrome: Assessment for Effective Intervention
| Autor: | Leopold M. G. Curfs, Marcel G. Smits, Karen Spruyt, W.J. Braam |
|---|---|
| Přispěvatelé: | RS: CAPHRI School for Public Health and Primary Care, RS: MHeNs - R3 - Neuroscience, Psychiatrie & Neuropsychologie, RS: GROW - R4 - Reproductive and Perinatal Medicine, Complexe Genetica, Genetica & Celbiologie, RS: CAPHRI - R2 - Creating Value-Based Health Care |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Sleep Wake Disorders medicine.medical_specialty Pediatrics Insomnia Sleep onset Radioimmunoassay Melatonin 03 medical and health sciences Eating Young Adult 0302 clinical medicine Physiology (medical) Intervention (counseling) Internal medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Circadian rhythm Child Saliva Pharmacology Awakening Age Factors Original Articles Middle Aged Smith–Magenis syndrome medicine.disease Sleep in non-human animals Circadian Rhythm Clinical trial Psychiatry and Mental health Endocrinology Child Preschool Female medicine.symptom Smith-Magenis Syndrome Psychology Sleep 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | CNS Neuroscience & Therapeutics, 22(11), 928-935. Wiley |
| ISSN: | 1755-5930 |
| Popis: | SummaryAims Individuals with Smith–Magenis syndrome (SMS) are reported to have a disrupted circadian rhythm. Our aim was to examine problematic sleeping in those attending our sleep clinic for the first time. Methods At intake, caregivers of 50 children and nine adults with SMS were surveyed about the sleep pattern and potential melatonin administration. Sampling of salivary melatonin levels was performed. Results At intake, exogenous melatonin was used by 16 children (27.1% of sample; 56.3% male) with mean age 6.8 ± 2.8 years, whereas 34 children (57.6%; 7.5 ± 4.8 years old; 64.7% male) and nine adults (15.3%; 36.8 ± 15.3 years old; 44.4% male) were not taking melatonin at intake. Participants were reported to have problems with night waking and early awakenings regardless of melatonin administration. Overall, moderate to high levels of salivary melatonin at noon were found in individuals with SMS. In particular, children with SMS showed a disrupted melatonin pattern. Furthermore, the endogenous melatonin level, age, and gender may potentially interact, yielding the severity range of sleep disturbances reported in SMS. Conclusion Treatment of sleep problems in SMS is complex, and our findings may support person-centered sleep and medication management. Future clinical trials including larger groups may shed light on such approaches. |
| Databáze: | OpenAIRE |
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