Gross Pathologic Types of Hepatocellular Carcinoma in Italy
| Autor: | Erica Villa, Roberto Mazzanti, Angelo Andriulli, Antonio Ascione, Giovanni Gasbarrini, Tommaso Stroffolini, Cinzia Medaglia, Gian Ludovico Rapaccini, Gloria Taliani, Maddalena Albanese, Maria Elena Tosti, Onofrio Giuseppe Manghisi, Antonio Craxì, Pietro Andreone, Giampaolo Pilleri, Maria Chiaramonte, Domenico Galante |
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| Rok vydání: | 1999 |
| Předmět: |
Male
HCC pathology Cancer Research Pathology medicine.medical_specialty Carcinoma Hepatocellular business.industry Liver Neoplasms Nodule (medicine) General Medicine Middle Aged medicine.disease digestive system diseases Gross examination Logistic Models Italy Oncology Hepatocellular carcinoma Prevalence Humans Medicine Female Hepatitis Antibodies medicine.symptom business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000011963 |
| Popis: | The prevalence and independent predictors of the different macroscopic types of hepatocellular carcinoma (HCC) were assessed in 1,073 unselected patients of 14 hospitals in Italy from May 1996 to May 1997. Solitary HCC was the most common cancer type (44.6%), followed by multinodular (44.2%), diffuse (8.4%) and massive (2.8%) types. After adjustment for the influence of confounders by multiple logistic regression analysis, Child-Pugh grades B and C were found to be independent predictors of multinodular (odds ratio, OR, 2.0; 95% confidence interval (CI) = 1.5–2.6) and diffuse (OR 2.6; 95% CI = 1.6–4.4) HCC types. These findings indicate that the majority of HCC cases are not detected at a potentially treatable stage. Delayed detection of HCC is associated with a higher likelihood of the multinodular or diffuse gross pathologic type. |
| Databáze: | OpenAIRE |
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