An adult co-presented with varicella and herpes zoster caused by varicella zoster virus genotype J, China: a case report

Autor: Wen-Ping Guo, Dan Li, Houguang Liu, Guang-Cheng Xie, Jiang-Li Wang, Ping-Ping Sun, Qiongling Wei
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
China
Herpesvirus 3
Human
medicine.medical_specialty
Genotype
Erythema
viruses
Herpes zoster
030106 microbiology
Human immunodeficiency virus (HIV)
Case Report
Physical examination
Varicella
medicine.disease_cause
Antiviral Agents
Ferric Compounds
Polymerase Chain Reaction
Polymorphism
Single Nucleotide
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Chickenpox
Medical microbiology
medicine
Humans
lcsh:RC109-216
Phylogeny
Treponema
integumentary system
medicine.diagnostic_test
biology
business.industry
Varicella zoster virus
virus diseases
biology.organism_classification
Dermatology
Drug Combinations
Treatment Outcome
030104 developmental biology
Infectious Diseases
Histamine H1 Antagonists
biology.protein
Zinc Oxide
medicine.symptom
Antibody
business
Zdroj: BMC Infectious Diseases
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-5 (2020)
ISSN: 1471-2334
Popis: Background Varicella zoster virus (VZV) causes varicella primarily in childhood, and some rare adults also report varicella. Herpes zoster mainly occurs in adults by endogenous reactivation of latent VZV. Until now, varicella and herpes zoster have seldom been reported simultaneously in one patient. Here, we report a rare case co-presenting with varicella and herpes zoster in a Chinese adult. Case presentation A 44-year-old Chinese man suffered papules and vesicles with pain on the left ear. Five days after onset, he was admitted to the Department of Dermatology of The Third Hospital of Xiamen. Physical examination revealed that small vesicles surrounded by erythema had developed on his trunk, back and neck, and unilateral papules and vesicles in ribbons had also developed on the left ear. This patient was excluded from human immunodeficiency virus and Treponema pallidum infections by ELISA antibody tests. Laboratory tests revealed that the ratio of eosinophils (0.1%) and eosinophil count (0.0 × 109/L) were significantly downregulated. Treatment with valacyclovir, ebastine, mecobalamine, pregabalin and calamine lotion for 5 days was effective therapy for varicella and herpes zoster. Polymerase chain reaction for vesicular fluids from varicella and herpes zoster was positive for VZV, and further phylogenetic analysis and single nucleotide polymorphism variations confirmed that the VZV genotype was type J (clade 2). Conclusions This rare case highlights awareness of varicella and herpes zoster caused by VZV infection in adults. Our report provides novel insight into the rare clinical presentation of VZV genotype J.
Databáze: OpenAIRE
Externí odkaz: