The Expression of Tumor-Associated Macrophages and Multinucleated Giant Cells in Papillary Thyroid Carcinoma
| Autor: | Maya Gulubova, Koni Ivanova |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty endocrine system diseases review MHC I and II antigen presentation lcsh:Medicine 030209 endocrinology & metabolism Inflammation Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine Multinucleate Basic Science medicine 030212 general & internal medicine Tumor microenvironment business.industry CD68 cross presentation Thyroid lcsh:R General Medicine Th polarization medicine.anatomical_structure Classical dendritic cells Giant cell Tumor progression plasmacytoid dendritic cells medicine.symptom business |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences, Vol 7, Iss 23 (2019) Open Access Macedonian Journal of Medical Sciences; Vol. 7 No. 23 (2019): Dec 15 (OAMJMS); 3944-3949 Open Access Macedonian Journal of Medical Sciences |
| ISSN: | 1857-9655 3944-3949 |
| Popis: | BACKGROUND: Inflammation that occurred in the tumor microenvironment was characterized by abundant macrophage infiltration, playing role in innate immunity. Multinucleate giant cells (MGCs) occur in a variety of inflammatory, hyperplastic, and neoplastic thyroid disorders. They also have been recognized as a feature of papillary thyroid carcinoma (PTC). AIM: The aim of this study was to evaluate cases of PTC for the presence of macrophages, and estimate CD68+ TAMs density in tumor stroma, margin and the surrounding tissue. We assessed also MGCs. METHODS: Macrophages and MGCs densities were correlated with clinicopathologic parameters to assess the possible prognostic significance. We investigated 56 patients immunohistochemically and immunofluorescence with antibodies against CD68 and IL-17. RESULTS: A statistically significant correlation was established between PTC patients in III stage, containing many MGCs, and PTC in I and II stage, with many MGCs. Eighty Percent of patients in III stage showed many MGCs in comparison with patients in I and II stage, where many MGCs were found only in 21,1% (χ2 = 6.189, p = 0.013). CONCLUSION: Our study demonstrates that the increased density of MGCs is associated with advanced stage of PTC, and therefore with tumor progression and that cases of PTC should be carefully screened for their presence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|