EndoPredict versus uPA/PAI‐1 in breast cancer: comparison of markers and association with clinicopathological parameters

Autor:	Reinhard Hoffmann, Thomas Kröncke, Benedikt Martin, Gerhard Schenkirsch, Thomas Jung, Jörg Kriegsmann, Bruno Märkl, Elzbieta Jakubowicz, Dieter Steinfeld, Roman Steierl
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Oncology medicine.medical_specialty Adjuvant chemotherapy Concordance medicine.medical_treatment Breast Neoplasms 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Breast cancer Internal medicine Plasminogen Activator Inhibitor 1 Internal Medicine medicine Biomarkers Tumor Humans Grading (tumors) Retrospective Studies Chemotherapy business.industry Urokinase Plasminogen Activator Middle Aged medicine.disease Urokinase-Type Plasminogen Activator Gene Expression Regulation Neoplastic Chemotherapy Adjuvant 030220 oncology & carcinogenesis Upa pai 1 Surgery Female business Plasminogen activator
Popis:	We retrospectively investigated concordance of EndoPredict (EPclin) with urokinase plasminogen activator and plasminogen activator inhibitor-1 (uPA/PAI-1) in 72 breast cancer patients and compared the results with grading, molecular subtype and chemotherapy recommendation. Compared to uPA/PAI-1, EPclin proved to be more conservative concerning correlation with clinicopathological parameters and was significantly associated with the recommendation of adjuvant chemotherapy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b144ec04b61045a362eb12e5ecfd6530 https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/56344 Zobrazit plný text záznamu