Transposable elements, circular RNAs and mitochondrial transcription in age-related genomic regulation
Autor: | Séverine Nozownik, Prakroothi S. Danthi, Bérénice A. Benayoun, Juan I. Bravo |
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Rok vydání: | 2020 |
Předmět: |
Transposable element
Aging 0303 health sciences RNA Circular Computational biology Mitochondrion Biology Phenotype Genomic Instability Mitochondria Transcriptome MicroRNAs 03 medical and health sciences 0302 clinical medicine Ribonucleoproteins Alu Elements Age related Mitochondrial transcription DNA Transposable Elements Animals Humans Molecular Biology 030217 neurology & neurosurgery 030304 developmental biology Developmental Biology |
Zdroj: | Development. 147 |
ISSN: | 1477-9129 0950-1991 |
Popis: | Our understanding of the molecular regulation of aging and age-related diseases is still in its infancy, requiring in-depth characterization of the molecular landscape shaping these complex phenotypes. Emerging classes of molecules with promise as aging modulators include transposable elements, circRNAs and the mitochondrial transcriptome. Analytical complexity means that these molecules are often overlooked, even though they exhibit strong associations with aging and, in some cases, may directly contribute to its progress. Here, we review the links between these novel factors and age-related phenotypes, and we suggest tools that can be easily incorporated into existing pipelines to better understand the aging process. |
Databáze: | OpenAIRE |
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