Current concepts in normal and defective angiogenesis: Implications for systemic sclerosis
| Autor: | Michael Simons, Mary Jo Mulligan-Kehoe |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Wound Healing
medicine.medical_specialty Scleroderma Systemic Neovascularization Pathologic Angiogenesis business.industry Neovascularization Physiologic medicine.disease Scleroderma Rheumatology Neovascularization Connective Tissue Fibrosis Internal medicine Immunology medicine Endothelial cell apoptosis Humans medicine.symptom Wound healing business |
| Zdroj: | Current Rheumatology Reports. 9:173-179 |
| ISSN: | 1534-6307 1523-3774 |
| DOI: | 10.1007/s11926-007-0013-2 |
| Popis: | Vascular abnormalities are a major component of systemic sclerosis, but little is known about the events or mechanisms that initiate vascular injury and prevent its repair. Early stages of systemic sclerosis are characterized by an exaggerated angiogenic response later replaced by defective wound healing and fibrosis. In this review, we summarize the current knowledge of the angiogenic imbalance in systemic sclerosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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