Concomitant administration of recombinant PsaA and PCV7 reduces Streptococcus pneumoniae serotype 19A colonization in a murine model
| Autor: | Erica Mauro, Annie Stinson-Parks, Scott E. Johnson, Sandra Romero-Steiner, George M. Carlone, Gowrisankar Rajam, Melissa J. Whaley, Edwin W. Ades, Jacquelyn S. Sampson, Patricia F. Holder |
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| Rok vydání: | 2009 |
| Předmět: |
Serotype
Heptavalent Pneumococcal Conjugate Vaccine Lipoproteins Biology medicine.disease_cause complex mixtures Microbiology Pneumococcal Vaccines Mice stomatognathic system Antigen Phagocytosis Conjugate vaccine Streptococcal Infections Streptococcus pneumoniae medicine Animals Colonization Vaccines Combined Adhesins Bacterial General Veterinary General Immunology and Microbiology Immunogenicity Public Health Environmental and Occupational Health Opsonin Proteins Virology Antibodies Bacterial Bacterial adhesin Infectious Diseases Carrier State Molecular Medicine |
| Zdroj: | Vaccine. 28(18) |
| ISSN: | 1873-2518 |
| Popis: | A murine colonization model was used to determine the effect of co-administering 7-valent polysaccharide-protein conjugate vaccine and pneumococcal surface adhesin A. Mice were challenged intranasally with either PCV7 serotypes, 4 or 14, or a non-PCV7 serotype, 19A. Post-challenge samples were evaluated for IgG antibody levels, opsonophagocytic activity, and nasopharyngeal colonization. No interference was observed between immune responses from the concomitant and individual immunizations. Concomitant immunizations reduced carriage for tested serotypes; largest reduction was observed for 19A. From these mouse studies, co-administering pneumococcal antigens appear to expand coverage and reduce colonization against a non-PCV7 serotype without inhibiting immunogenicity to other serotypes. |
| Databáze: | OpenAIRE |
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