The Effect of Various Contrast Media on the Activation of Plasminogen by Streptokinase or Recombinant Tissue Plasminogen Activator In Vitro
| Autor: | A Schilvold, C Ing, S Bjørnsen, F Brosstad |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Gadolinium DTPA
Plasmin Iohexol medicine.medical_treatment Streptokinase Contrast Media Gadolinium Triiodobenzoic Acids Fibrinolysis Ioxaglic Acid Organometallic Compounds medicine Humans Radiology Nuclear Medicine and imaging Fibrinolysin Dose-Response Relationship Drug Chromogenic Chemistry Fibrinogen Substrate (chemistry) Plasminogen Metrizoic Acid General Medicine Pentetic Acid In vitro Dose–response relationship Coagulation Tissue Plasminogen Activator Biophysics medicine.drug |
| Zdroj: | Investigative Radiology. 29:705-708 |
| ISSN: | 0020-9996 |
| Popis: | Rationale and objectives Radiologic contrast media (CM) may influence processes of coagulation and fibrinolysis. In the current study, the effects of various CM on the formation of plasmin were examined in an in vitro buffer system. Methods The effects of three clinically relevant concentrations of seven different iodine-containing CM and gadolinium-DTPA on streptokinase (SK) or recombinant tissue plasminogen activator (rt-PA)-induced plasmin formation was monitored using a plasmin-sensitive chromogenic substrate. Results Contrast media generally had an inhibitory effect at the plasminogen activation step; this effect was particularly noticeable with the ionic CM. Conclusions Contrast media influence plasminogen activation by SK and rt-PA in vitro. Ionic CM have a more pronounced inhibitory effect than the nonionic media. The ionic Gd-DTPA shows a less inhibitory effect than the ionic iodine-containing CM. However, they must be regarded separately because of the different chemical composition of the magnetic resonance imaging and x-ray CM. |
| Databáze: | OpenAIRE |
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