Effects of Age on Esophageal Motility: A High-Resolution Manometry Study
| Autor: | Mickael Bouin, Roupen Djinbachian, Etienne Marchand, Weixiang Yan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
medicine.medical_specialty Manometry business.industry Esophageal motility disorders Reflux General Medicine Chest pain medicine.disease Gastroenterology Dysphagia Esophagus medicine.anatomical_structure Esophageal motility disorder Interquartile range Bayesian multivariate linear regression Internal medicine medicine Original Article medicine.symptom business Esophageal motility |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| DOI: | 10.14740/jocmr4576 |
| Popis: | Background: Studies have found possible physiologic changes to esophageal motility with aging currently not taken into account in routine high-resolution manometry (HRM) interpretation. We aimed to quantify the relationship between these physiologic changes and aging to improve HRM interpretation. Methods: We conducted a retrospective analysis of patients who underwent HRM at a tertiary hospital center between 2015 and 2019. Inclusion criteria were patients aged >= 18 years with normal HRM. Exclusion criteria were abnormal HRM, abnormal upper digestive endoscopy or imagery. Outcomes were median integrated relaxation pressure (IRP), lower esophageal sphincter (LES) pressure, distal contractal integral (DCI), distal latency (DL), and peristaltic break (PB) according to the v4.0 Chicago classification criteria. Effect of age was examined through univariate and multivariate linear regression analysis. Results: We identified 1,917 patients with HRM and included 722 patients with normal exams (median age 56 years (interquartile range (IQR) 46 - 66), 63.8% female). Indications for HRM included dysphagia (39.6%), gastroesophageal reflux disease (29.5%), and chest pain (11.5%). There was statistically significant relationship between age and IRP (r = 0.20, P < 0.0001) as well as DCI (r = 0.12, P = 0.001) and DL (r = -0.09, P = 0.02). No statistically significant relationship was found between age and LES pressure or PB. Conclusion: We found that IRP, DCI, and to a lesser extent, DL, are significantly correlated with the normal aging process in symptomatic patients. These findings should be taken into consideration when interpreting esophageal HRM. J Clin Med Res. 2021;13(8):413-419 doi: https://doi.org/10.14740/jocmr4576 |
| Databáze: | OpenAIRE |
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