ACE Insertion/Deletion polymorphism (rs4646994) affects body composition in middle-aged premenopausal women with essential hypertension
| Autor: | Veronika Čerňanová, Darina Falbová, Daniela Siváková, Radoslav Beňuš, Lenka Vorobeľová |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Genetics
body composition hypertension Health (social science) business.industry 030232 urology & nephrology snp 030209 endocrinology & metabolism Essential hypertension medicine.disease GN1-890 03 medical and health sciences 0302 clinical medicine Anthropology medicine Insertion deletion business ace |
| Zdroj: | Anthropological Review, Vol 82, Iss 4, Pp 349-355 (2019) |
| ISSN: | 2083-4594 1898-6773 |
| DOI: | 10.2478/anre-2019-0026 |
| Popis: | This study assesses the association between angiotensin converting enzyme (ACE) I/D (rs4646994) polymorphism and body composition parameters in essential hypertension (HT) and menopausal status in Slovak women. The entire study sample comprised 575 women in two groups: 255 with HT and 320 without. Body composition parameters were measured by bioelectric impedance analyzer and ACE I/D polymorphism genotypes were detected by polymerase chain reaction. Premenopausal HT women with ACE II genotype had significantly lower body cell mass (p=0.004), extra- and intracellular water (p=0.027; p=0.004), fat free mass and muscle mass (p=0.006; P = 0.003), fat free mass index (p=0.006) and body cell mass index (p=0.003) than their ID/DD counterparts. These associations were not determined in normotensive and/or postmenopausal women. This study confirmed that ACE I/D gene polymorphism affects body composition in HT premenopausal women. |
| Databáze: | OpenAIRE |
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