Catalyst Control in Switching the Site Selectivity of C-H Olefinations of 1,2-Dihydroquinolines: An Approach to Positional-Selective Functionalization of Quinolines

Autor:	Nandkishor Prakash Khot, Manmohan Kapur, Akanksha Santosh Deshpande, Riki Das
Rok vydání:	2019
Předmět:	Reaction conditions Site selectivity Organic Chemistry Quinoline chemistry.chemical_element Substrate (chemistry) General Chemistry Combinatorial chemistry Catalysis Ruthenium chemistry.chemical_compound chemistry Surface modification Palladium
Zdroj:	Chemistry (Weinheim an der Bergstrasse, Germany). 26(4)
ISSN:	1521-3765
Popis:	A unique approach to achieve site-selective C-H olefinations exclusively at the C-3- or C-8-positions in the quinoline framework has been developed by catalyst control. Distal C(3)-H functionalization is achieved by using palladium catalysis, whereas proximal C(8)-H functionalization is obtained by employing ruthenium catalysis. Switching the site selectivity within a single substrate directly indicates two diverse pathways, which are operating under the palladium- and ruthenium-catalyzed reaction conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b13c6370f8e4193dc18552c223e7724f https://pubmed.ncbi.nlm.nih.gov/31625636 Zobrazit plný text záznamu Plný text