Comprehensive Profiling of Inflammatory Factors Revealed That Growth Differentiation Factor-15 Is an Indicator of Disease Severity in COVID-19 Patients
Autor: | Xiangyun Teng, Jiaqi Zhang, Yaling Shi, Yuntao Liu, Yanqing Yang, Jinyong He, Shuhong Luo, Yile Huang, Yanxia Liu, Dongdong Liu, Yizhe Li, Shuangzhe Zhang, Ruo-Pan Huang, Dawei Wang, Jianhua Xu |
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Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Growth Differentiation Factor 15 Immunology Disease macromolecular substances Asymptomatic Gastroenterology Severity of Illness Index 03 medical and health sciences Young Adult 0302 clinical medicine inflammatory factors Internal medicine White blood cell Severity of illness Immunology and Allergy Medicine Humans Aged Retrospective Studies Original Research business.industry SARS-CoV-2 COVID-19 Computational Biology Retrospective cohort study RC581-607 Middle Aged 030104 developmental biology medicine.anatomical_structure GDF15 nervous system Absolute neutrophil count Biomarker (medicine) biomarker Female disease severity Immunologic diseases. Allergy medicine.symptom Inflammation Mediators business 030217 neurology & neurosurgery Biomarkers |
Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 12 (2021) |
ISSN: | 1664-3224 |
Popis: | To systematically explore potential biomarkers which can predict disease severity in COVID-19 patients and prevent the occurrence or development of severe COVID-19, the levels of 440 factors were analyzed in patients categorized according to COVID-19 disease severity; including asymptomatic, mild, moderate, severe, convalescent and healthy control groups. Factor candidates were validated by ELISA and functional relevance was uncovered by bioinformatics analysis. To identify potential biomarkers of occurrence or development of COVID-19, patient sera from three different severity groups (moderate, severe, and critical) at three time points (admission, remission, and discharge) and the expression levels of candidate biomarkers were measured. Eleven differential factors associated with disease severity were pinpointed from 440 factors across 111 patients of differing disease severity. The dynamic changes of GDF15 reflect the progression of the disease, while the other differential factors include TRAIL R1, IGFBP-1, IGFBP-4, VCAM-1, sFRP-3, FABP2, Transferrin, GDF15, IL-1F7, IL-5Rα, and CD200. Elevation of white blood cell count, neutrophil count, neutrophil-lymphocyte ratio (NLR), Alanine aminotransferase and Aspartate aminotransferase, low lymphocyte and eosinophil counts in the severe group were associated with the severity of COVID-19. GDF15 levels were observed to be associated with the severity of COVID-19 and the dynamic change of GDF15 levels was closely associated with the COVID-19 disease progression. Therefore, GDF15 might serve as an indicator of disease severity in COVID-19 patients. |
Databáze: | OpenAIRE |
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