Cancer-Nano-Interaction: From Cellular Uptake to Mechanobiological Responses
| Autor: | Ahmad Sohrabi Kashani, Muthukumaran Packirisamy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
QH301-705.5
Cellular functions Context (language use) Review 02 engineering and technology Biology Catalysis Inorganic Chemistry 03 medical and health sciences Mechanobiology cell mechanics Neoplasms medicine Humans Biology (General) Physical and Theoretical Chemistry QD1-999 Molecular Biology Cell mechanics Spectroscopy 030304 developmental biology 0303 health sciences Structural organization nanoparticle Organic Chemistry nano-bio-interaction Cancer Biological Transport General Medicine 021001 nanoscience & nanotechnology medicine.disease 3. Good health Computer Science Applications Chemistry migratory index Cancer cell cancer cells Nanoparticles 0210 nano-technology Neuroscience mechanobiological properties |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 9587, p 9587 (2021) |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms22179587 |
| Popis: | With the advancement of nanotechnology, the nano-bio-interaction field has emerged. It is essential to enhance our understanding of nano-bio-interaction in different aspects to design nanomedicines and improve their efficacy for therapeutic and diagnostic applications. Many researchers have extensively studied the toxicological responses of cancer cells to nano-bio-interaction, while their mechanobiological responses have been less investigated. The mechanobiological properties of cells such as elasticity and adhesion play vital roles in cellular functions and cancer progression. Many studies have noticed the impacts of cellular uptake on the structural organization of cells and, in return, the mechanobiology of human cells. Mechanobiological changes induced by the interactions of nanomaterials and cells could alter cellular functions and influence cancer progression. Hence, in addition to biological responses, the possible mechanobiological responses of treated cells should be monitored as a standard methodology to evaluate the efficiency of nanomedicines. Studying the cancer-nano-interaction in the context of cell mechanics takes our knowledge one step closer to designing safe and intelligent nanomedicines. In this review, we briefly discuss how the characteristic properties of nanoparticles influence cellular uptake. Then, we provide insight into the mechanobiological responses that may occur during the nano-bio-interactions, and finally, the important measurement techniques for the mechanobiological characterizations of cells are summarized and compared. Understanding the unknown mechanobiological responses to nano-bio-interaction will help with developing the application of nanoparticles to modulate cell mechanics for controlling cancer progression. |
| Databáze: | OpenAIRE |
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