CDK8 Expression in Extrauterine Leiomyosarcoma Correlates With Tumor Stage and Progression
| Autor: | Oleksandr Yergiyev, Alka Palekar, Uma N. M. Rao, David L. Bartlett, George Garib, Karen E. Schoedel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Leiomyosarcoma Male 0301 basic medicine Pathology medicine.medical_specialty Histology Biology medicine.disease_cause Pathology and Forensic Medicine MED12 Metastasis 03 medical and health sciences 0302 clinical medicine Mediator Coactivator Biomarkers Tumor medicine Humans Aged Neoplasm Staging Aged 80 and over Mediator Complex Leiomyoma Middle Aged Cyclin-Dependent Kinase 8 medicine.disease Immunohistochemistry Medical Laboratory Technology 030104 developmental biology 030220 oncology & carcinogenesis Female Neoplasm Recurrence Local Carcinogenesis |
| Zdroj: | Applied Immunohistochemistry & Molecular Morphology. 26:161-164 |
| ISSN: | 1541-2016 |
| DOI: | 10.1097/pai.0000000000000409 |
| Popis: | Mediator is a multiprotein complex that acts as a versatile transcription coactivator in eukaryotes. CDK8 kinase complex is a 4-protein subunit of the mediator complex that can act as a transcriptional repressor or coactivator, depending on the specific pathways involved. Although the role of MED12 exon 2 mutations is documented in the pathogenesis of uterine leiomyomas, its role in extrauterine smooth muscle tumorigenesis is less clear. Similarly, there is a paucity of data on the role of CDK8 in extrauterine smooth muscle tumorigenesis and progression. Our study correlates immunohistochemical expression of CDK8 and MED12 with clinical and pathologic parameters in extrauterine leiomyosarcomas. Immunohistochemical expression of CDK8 and MED12 in leiomyosarcomas was correlated with the tumor grade, stage, and the presence of local recurrence or metastasis. MED12 was expressed in the majority of leiomyosarcomas regardless of their stage or grade. CDK8 expression was lost in 1 of 6 pT1 tumors, compared with 9 of 10 pT2 tumors (P=0.0076). When the second group was expanded to include those tumors that did not have a recorded pathologic stage but had local recurrence and distant metastases, the difference in CDK8 expression was also statistically significant. Loss of CDK8 expression by immunohistochemistry is more prevalent in somatic leiomyosarcomas presenting at a higher histopathologic stage, as well as with local and distant recurrence, and can be used to enhance the current predictive parameters. |
| Databáze: | OpenAIRE |
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