Peripheral Blood Mononuclear Cell (PBMC) Responsiveness in Patients with Head and Neck Cancer in Relation to Tumour Stage and Prognosis
| Autor: | Hans Jørgen Aarstad, John-Helge Heimdal, Jan Olofsson, Beate Klementsen |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
Pathology medicine.medical_specialty T-Lymphocytes Peripheral blood mononuclear cell Immunopathology Humans Medicine In patient Neoplasm Staging business.industry Monocyte Head and neck cancer General Medicine T lymphocyte Prognosis medicine.disease Survival Analysis Head and neck squamous-cell carcinoma stomatognathic diseases medicine.anatomical_structure Otorhinolaryngology Epidermoid carcinoma Head and Neck Neoplasms Carcinoma Squamous Cell Leukocytes Mononuclear business |
| Zdroj: | Acta Oto-Laryngologica. 119:281-284 |
| ISSN: | 1651-2251 0001-6489 |
| DOI: | 10.1080/00016489950181828 |
| Popis: | We have previously shown an increased T lymphocyte and monocyte responsiveness in peripheral blood mononuclear cells (PBMC) from patients with head and neck squamous cell carcinoma (HNSCC) compared with PBMC from control patients. This study reports T lymphocyte function of PBMC of 81 patients with HNSCC dependent on disease stage and prognosis. Males with HNSCC under 80 years of age without cachexia, with no auto-immune disease or previous cancer and on no immuno-active medication were included at the time of diagnosis of disease. The follow-up was for at least 18 months. When cells from patients with early vs late stage disease according to the T, N or T + N stage of HNSCC were compared, decreased in vitro mitogen-stimulated and spontaneous T cell proliferation was seen with increasing tumour stage. When patients were studied according to disease-specific survival, a decreased T lymphocyte mitogen-stimulated proliferation was observed to be associated with a poorer prognosis. No changes in prognosis were noticed related to decreased gamma-IFN, IL-2 or IL-4 level of the supernatants of the T lymphocyte-stimulated PBMC in vitro cultures. With stratification for disease stage, we determined that PBMC in vitro T lymphocyte-stimulated proliferation predicted outcome for the HNSCC patients. The results were similar for both laryngeal and oral cavity/pharyngeal cancers. The present investigation provides evidence to support the idea that the relationship between HNSCC and the immune system of the host may provide clinically useful information about prognosis. |
| Databáze: | OpenAIRE |
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