Effects of short-term anti-inflammatory glucocorticoid treatment on clinicopathologic, echocardiographic, and hemodynamic variables in systemically healthy dogs
| Autor: | Jessica L. Ward, Natalie R. Langenfeld, Darren J. Berger, Allison K. Masters, Johann F. Coetzee, Wendy A. Ware, Jonathan P. Mochel |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Heart Diseases 040301 veterinary sciences Anti-Inflammatory Agents Hemodynamics Blood Pressure 030204 cardiovascular system & hematology Gastroenterology 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Blood serum Dogs Prednisone Internal medicine medicine Eosinopenia Animals Dog Diseases Glucocorticoids Heart Failure General Veterinary business.industry 04 agricultural and veterinary sciences General Medicine medicine.disease Neutrophilia Blood pressure Blood chemistry Echocardiography Heart failure Dermatitis Allergic Contact Potassium Female medicine.symptom business medicine.drug |
| Zdroj: | American journal of veterinary research. 79(4) |
| ISSN: | 1943-5681 |
| Popis: | OBJECTIVE To investigate mechanisms by which anti-inflammatory doses of orally administered intermediate-acting glucocorticoids (prednisone) could predispose dogs to progression of heart disease or congestive heart failure. ANIMALS 11 client-owned dogs with allergic dermatitis and 11 matched healthy control dogs. PROCEDURES Clinicopathologic, echocardiographic, and hemodynamic variables were measured. Dogs with allergic dermatitis then received prednisone (1 mg/kg, PO) once daily for 14 consecutive days beginning on day 0 (baseline), followed by a tapering and washout period; control dogs received no treatment. Measurements were repeated on days 7, 14, and 35. Linear mixed modeling was used to compare changes in variables across measurement points and between dog groups. RESULTS Prednisone administration caused no significant changes in serum sodium or potassium concentration, blood glucose concentration, or target echocardiographic variables. The change from baseline in systolic arterial blood pressure at day 7 was significantly greater in prednisone-treated dogs than in control dogs. Expected changes in hematologic and serum biochemical values with prednisone administration (neutrophilia, eosinopenia, isosthenuria, and high serum alkaline phosphatase and alanine aminotransferase activities) also occurred in the prednisone-treated dogs. CONCLUSIONS AND CLINICAL RELEVANCE Findings suggested that anti-inflammatory doses of orally administered glucocorticoids have the potential to adversely impact cardiac function in dogs by causing an increase in blood pressure and thus increased cardiac afterload. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|