Broxaterol increases force output of fatigued canine diaphragm more than salbutamol
| Autor: | G Gurrieri, E Derom, Marc Decramer, V de Bock, Ghislaine Gayan-Ramirez |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.drug_class Diaphragm Broxaterol Critical Care and Intensive Care Medicine Contractility chemistry.chemical_compound Bolus (medicine) Dogs Bronchodilator medicine Respiratory muscle Animals Albuterol Muscle fatigue biology business.industry Fissipedia Isoxazoles Adrenergic beta-Agonists biology.organism_classification chemistry Anesthesia Muscle Fatigue Salbutamol business medicine.drug Muscle Contraction |
| Zdroj: | American journal of respiratory and critical care medicine. 155(1) |
| ISSN: | 1073-449X |
| Popis: | We previously demonstrated that broxaterol enhanced recovery of fatigued canine diaphragm. The aim of this study was to compare the inotropic effects of salbutamol and broxaterol on fatigued canine diaphragm. Low-frequency fatigue was induced in 14 mongrel dogs by electrophrenic stimulation, which was continued until transdiaphragmatic pressure (Pdi) at 20 Hz was reduced by 50% or for 1 h. After stabilization of fatigue, the animals received a bolus (18.5 microg/kg) of either broxaterol or salbutamol, followed by a continuous infusion (0.43 microg/kg/min). A second bolus of 74.0 microg/kg, followed by a continuous infusion of 1.72 microg/kg/min, was given after 90 min. Both drugs significantly increased twitch Pdi. Twitch Pdi measured 90 min after the first and second doses of broxaterol increased by 28 +/- 23% and 42 +/- 34%, respectively, whereas the salbutamol-induced increase was clearly smaller (9 +/- 10% and 17 +/- 15%, respectively). Broxaterol increased Pdi at 20 Hz by 25 +/- 28% with the first dose and by 29 +/- 21% with the second dose. In contrast, salbutamol did not alter Pdi at 20 Hz. Neither drug affected Pdi at 100 Hz. We conclude that broxaterol promoted recovery of low-frequency fatigue of the canine diaphragm in vivo in a dose-dependent manner, whereas salbutamol only minimally improved force production by the fatigued diaphragm. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|