Microfluidic pH-sensing chips integrated with pneumatic fluid-control devices
| Autor: | Wei-Yin Liao, Tse-Chuan Chou, Chen-Fu Lin, Gwo-Bin Lee, Huei-Huang Lee, Chih-Hao Wang |
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| Rok vydání: | 2006 |
| Předmět: |
Materials science
Transducers Microfluidics Biomedical Engineering Biophysics Analytical chemistry Micropump Reference electrode chemistry.chemical_compound Electrochemistry Miniaturization Microelectromechanical systems Microchannel Polydimethylsiloxane business.industry Equipment Design General Medicine Hydrogen-Ion Concentration Microfluidic Analytical Techniques Chip Equipment Failure Analysis Systems Integration chemistry Flow Injection Analysis Optoelectronics business Microelectrodes Ion-Selective Electrodes Biotechnology |
| Zdroj: | Biosensors and Bioelectronics. 21:1468-1475 |
| ISSN: | 0956-5663 |
| DOI: | 10.1016/j.bios.2005.06.005 |
| Popis: | This paper presents a microfluidic chip capable of performing precise continuous pH measurements in an automatic mode. The chip is fabricated using micro-electro-mechanical-systems (MEMS)-based techniques and incorporates polydimethylsiloxane (PDMS) microstructures, pH-sensing electrodes and pneumatic fluid-control devices. Through its enhanced microchannel design and use of pneumatic fluid-control devices, the microfluidic chip reduces the dead volume of the sample and increases the pumping rate. The maximum pumping rate of the developed micro-pump is 28 microL/min at an air pressure of 10 psi and a driving frequency of 10 Hz. The total sample volume consumed in each sensing operation is just 0.515 microL. As a result, the developed chip reduces the sample volume compared to conventional large-scale pH-sensing systems. The microfluidic chip employs the electrochemical sensing method to conduct precise pH level measurements. The sensing electrodes are fabricated by sputtering a layer of SiO(2)-LiO(2)-BaO-TiO(2)-La(2)O(3) (SLBTLO) onto platinum (Pt) electrodes and the pH value of the sample is evaluated by measuring the potential difference between the sensing electrodes and a reference electrode. Additionally, the integration of the microfluidic chip with a pneumatic fluid-control device facilitates automatic sample injection and a continuous sensing operation. The developed system provides a valuable tool with which to examine pH values in a wide range of biomedical and industrial applications. |
| Databáze: | OpenAIRE |
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