PowerfulDrosophilascreens that paved the wingless pathway
| Autor: | Fabian H. Jenny, Konrad Basler |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Wnt1 Protein
Review Chromosomes Wnt Animals Drosophila Proteins genetics development genetic screens Genetics Regulation of gene expression biology wingless signaling Wnt signaling pathway LRP6 β-catenin biology.organism_classification Wnt signaling Phenotype Cell biology Drosophila melanogaster Gene Expression Regulation Insect Science Signal transduction Wg Drosophila Protein Signal Transduction Genetic screen |
| Zdroj: | Fly |
| ISSN: | 1933-6942 1933-6934 |
| Popis: | The Wnt/Wingless (Wg) signaling cascade controls a number of biological processes in animal development and adult life; aberrant Wnt/Wg signaling can cause diseases. In the 1980s genes were discovered that encode core Wnt/Wg pathway components: their mutant phenotypes were similar and an outline of a signaling cascade emerged. Over the years our knowledge of this important signaling system increased and more components were uncovered that are instrumental for Wnt/Wg secretion and transduction. Here we provide an overview of these discoveries, the technologies involved, with a particular focus on the important role Drosophila screens played in this process. |
| Databáze: | OpenAIRE |
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