Polymorphisms in the interleukin-12/18 genes and recurrent spontaneous abortion
| Autor: | Helena Meden-Vrtovec, Borut Peterlin, Marija Volk, Saša Ostojić, Miljenko Kapović, Igor Medica |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Abortion Habitual medicine.medical_specialty Genotype medicine.medical_treatment Immunology Abortion Biology Polymerase Chain Reaction Polymorphism Single Nucleotide Gastroenterology Pregnancy Internal medicine medicine Humans Immunology and Allergy Genetic Predisposition to Disease Electrophoresis Agar Gel Interleukin-12 Subunit p40 Interleukin-18 Genetic Variation Obstetrics and Gynecology Interleukin Promoter DNA Cytokine Reproductive Medicine Case-Control Studies Interleukin 12 Female Interleukin 18 Gene polymorphism gene polymorphism interleukin-12 interleukin-18 recurrent spontaneous abortion |
| Popis: | Problem Interleukin (IL) IL-12/IL-18 are involved in uterine NK cells control of uterine vascular development. Polymorphisms in the IL-12/IL-18 genes could modify the cytokine balance, which might result in an increased susceptibility to recurrent spontaneous abortion (RSA). Method of Study A case–control study was conducted to determine the association between the IL12 (I/D) and IL18 (−607C>A, −137G>C) gene polymorphisms and the risk of RSA in 125 women with RSA and in 136 controls. Results The frequencies of DD, ID, II for IL-12 were, 25.6%, 52.8% and 21.6% respectively, in patients versus 21.3%, 51.5% and 27.2% respectively in controls; the frequencies of CC, CA, AA genotypes for IL-18 (−607) were, 34.4%, 54.4% and 11.2% respectively in patients versus 30.1%, 58.1% and 11.8% respectively in controls; the frequencies of GG, GC, CC genotypes for IL-18(−137) were 47.2%, 43.2% and 9.6% respectively in patients and 45.6%, 46.3% and 8.1% respectively in controls. Conclusion IL-12B and IL-18 promoter gene polymorphisms were not associated with RSA in our women. |
| Databáze: | OpenAIRE |
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