Salt intake causes B-type natriuretic peptide elevation independently of blood pressure elevation in the general population without hypertension and heart disease
| Autor: | Hideo Yasuda, Akihiko Kato, Sayaka Ishigaki, Tomoyuki Fujikura, Shinsuke Isobe, Naro Ohashi, Taro Aoki, Takashi Matsuyama, Hiroyuki Takase |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty hypertension Heart disease medicine.drug_class Urinary system Population Observational Study heart disease general population 03 medical and health sciences 0302 clinical medicine Internal medicine Natriuretic Peptide Brain medicine Natriuretic peptide Humans 030212 general & internal medicine cardiovascular diseases Sodium Chloride Dietary Salt intake education Aged education.field_of_study Surrogate endpoint business.industry blood pressure General Medicine Middle Aged salt intake medicine.disease left ventricular hypertrophy Cross-Sectional Studies medicine.anatomical_structure Endocrinology Quartile Ventricle B-type natriuretic peptide 030220 oncology & carcinogenesis Female business hormones hormone substitutes and hormone antagonists Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Excessive salt intake causes hypertension and cardiovascular diseases (CVDs). B-type natriuretic peptide (BNP) is synthesized and released from the ventricle, and is a surrogate marker reflecting various CVDs. Moreover, when a slight BNP elevation is shown, it leads to a poor prognosis in the general population. However, the relationship between salt intake and BNP levels in the general population remains unclear, especially in those without hypertension and heart diseases. In this study, we recruited 1404 participants without hypertension and electrocardiogram abnormalities, who received regular annual health check-ups in Japan. Plasma BNP levels were measured, and daily salt intake levels were evaluated using urinary samples. In addition, some clinical parameters were obtained, and the data were cross-sectionally analyzed. The median of plasma BNP levels was 10.50 pg/mL, and daily salt intake was 8.50 ± 1.85 g. When dividing participants into quartiles according to daily salt intake, those with the highest daily salt intake revealed the highest plasma BNP levels. Plasma BNP levels were significantly and positively associated with daily salt intake. Moreover, multiple linear regression analyses revealed that plasma BNP levels showed a significant positive association with daily salt intake levels after adjustments. Plasma BNP levels were significantly and positively associated with daily salt intake after adjustment in the general population. Plasma BNP levels may be a surrogate marker reflecting salt-induced heart diseases. |
| Databáze: | OpenAIRE |
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