Computational reconstruction of ancestral genomic regions from evolutionarily conserved gene clusters

Autor: Etienne G.J. Danchin, Eric A. Gaucher, Pierre Pontarotti
Přispěvatelé: ProdInra, Migration, David A. Liberles, Université de Provence - Aix-Marseille 1, Evolution, Genome, Environnement (EGEE), Evolution et Diversité Biologique (EDB), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Zdroj: Ancestral Sequence Reconstruction
Ancestral Sequence Reconstruction, Oxford University Press, 272 p., 2007, 978-0199545575
Ancestral Sequence Reconstruction, oxford university press, pp.252, 2007, 9780199299188
Popis: Gene clusters that are evolutionarily conserved between different species can result from a common ancestral genomic region. By identifying and comparing conserved gene clusters between different taxa, it is possible to infer the gene content of the corresponding putative ancestral region, and hence it is possible to shed light on ancestral genomic organization. From selected genomic region in vertebrates, this chapter identifies evolutionarily conservation in other taxa as evolutionary distant as arthropods (i.e., Drosophila melanogaster and Anopheles gambiae). This is made possible through systematic phylogenetic analysis (for determining homology relationships) and stringent statistical testing (for evaluating the significance of the clusters' conservation). The comparison of these conserved gene clusters means that conceptual ancestral gene clusters in Urbilateria (the last common ancestor of all bilaterian species) can be deciphered. In order to reconstruct ancestral features at a larger genomic scale, it is possible to consider automation of the approach and important concepts are developed in this chapter.
Databáze: OpenAIRE
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