A lower global lung ultrasound score is associated with higher likelihood of successful extubation in invasively ventilated COVID-19 patients
| Autor: | Arthur Lieveld, Salvatore Grasso, Giacomo Errico, Gilda Cinnella, Luigi Pisani, Marcus J. Schultz, David De Bels, Jasper M. Smit, Valentina Marinelli, Laura A. Hagens, Micah L. A. Heldeweg, Lucia Mirabella, Charalampos Pierrakos, Lieuwe D. J. Bos, Marry R. Smit, Francesco Murgolo, Rachid Attou, Lars Veldhuis, Mark E. Haaksma, Robin Walburgh Schmidt, Claudio Zimatore, Pieter-Roel Tuinman, Cristina David |
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| Přispěvatelé: | Graduate School, Intensive Care Medicine, Emergency Department, ACS - Pulmonary hypertension & thrombosis, AII - Infectious diseases, ACS - Heart failure & arrhythmias, ACS - Diabetes & metabolism, ACS - Microcirculation, Internal medicine, Anesthesiology, Intensive care medicine, Pulmonary medicine, APH - Quality of Care |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
ARDS Internationality medicine.medical_treatment Cohort Studies Virology Intensive care medicine Humans Intubation Lung Aged Ultrasonography Mechanical ventilation SARS-CoV-2 business.industry Hazard ratio COVID-19 Articles Emergency department Middle Aged medicine.disease Confidence interval Infectious Diseases Anesthesia Airway Extubation Breathing Female Parasitology business |
| Zdroj: | American Journal of Tropical Medicine and Hygiene, 105(6), 1490-1497. AMER SOC TROP MED & HYGIENE Pierrakos, C, Lieveld, A, Pisani, L, Smit, M R, Heldeweg, M, Hagens, L A, Smit, J, Haaksma, M, Veldhuis, L, Schmidt, R W, Errico, G, Marinelli, V, Attou, R, David, C E, Zimatore, C, Murgolo, F, Grasso, S, Mirabella, L, Cinnella, G, de Bels, D, Schultz, M J, Tuinman, P-R & Bos, L D 2021, ' A lower global lung ultrasound score is associated with higher likelihood of successful extubation in invasively ventilated COVID-19 patients ', The American journal of tropical medicine and hygiene, vol. 105, no. 6, pp. 1490-1497 . https://doi.org/10.4269/ajtmh.21-0545 American journal of tropical medicine and hygiene, 105(6), 1490-1497. American Society of Tropical Medicine and Hygiene The American Journal of Tropical Medicine and Hygiene The American journal of tropical medicine and hygiene, 105(6), 1490-1497. American Society of Tropical Medicine and Hygiene |
| ISSN: | 0002-9637 |
| DOI: | 10.4269/ajtmh.21-0545 |
| Popis: | Lung ultrasound (LUS) can be used to assess loss of aeration, which is associated with outcome in patients with coronavirus disease 2019 (COVID-19) presenting to the emergency department. We hypothesized that LUS scores are associated with outcome in critically ill COVID-19 patients receiving invasive ventilation. This retrospective international multicenter study evaluated patients with COVID-19–related acute respiratory distress syndrome (ARDS) with at least one LUS study within 5 days after invasive mechanical ventilation initiation. The global LUS score was calculated by summing the 12 regional scores (range 0–36). Pleural line abnormalities and subpleural consolidations were also scored. The outcomes were successful liberation from the ventilator and intensive care mortality within 28 days, analyzed with multistate, competing risk proportional hazard models. One hundred thirty-seven patients with COVID-19–related ARDS were included in our study. The global LUS score was associated with successful liberation from mechanical ventilation (hazard ratio [HR]: 0.91 95% confidence interval [CI] 0.87–0.96; P = 0.0007) independently of the ARDS severity, but not with 28 days mortality (HR: 1.03; 95% CI 0.97–1.08; P = 0.36). Subpleural consolidation and pleural line abnormalities did not add to the prognostic value of the global LUS score. Examinations within 24 hours of intubation showed no prognostic value. To conclude, a lower global LUS score 24 hours after invasive ventilation initiation is associated with increased probability of liberation from the mechanical ventilator COVID–19 ARDS patients, independently of the ARDS severity. |
| Databáze: | OpenAIRE |
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