Constipation is Associated With Mild Cognitive Impairment in Patients With de novo Parkinson’s Disease
| Autor: | Seong-Beom Koh, Jungyeun Lee, Sung Hoon Kang |
|---|---|
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Constipation Parkinson's disease parkinson’s disease business.industry Neuropsychology Neurosciences. Biological psychiatry. Neuropsychiatry Cognition constipation Disease Logistic regression medicine.disease mild cognitive impairment Neurology Internal medicine medicine In patient Neurology. Diseases of the nervous system Neurology (clinical) medicine.symptom RC346-429 business Cognitive impairment frontal-executive function RC321-571 |
| Zdroj: | Journal of Movement Disorders, Vol 15, Iss 1, Pp 38-42 (2022) |
| ISSN: | 2093-4939 2005-940X |
| DOI: | 10.14802/jmd.21074 |
| Popis: | Objective The association between gastrointestinal (GI) symptoms and cognitive profile in patients with Parkinson’s disease (PD) at diagnosis remains unclear, although GI symptoms and cognitive impairment are highly prevalent in patients with PD. We investigated the relationship between constipation and cognitive status. We also aimed to identify the correlation between constipation and each neuropsychological dysfunction.Methods A total of 427 patients with de novo Parkinson’s disease with normal cognition (PD-NC, n = 170) and Parkinson’s disease with mild cognitive impairment (PD-MCI, n = 257) at Korea University Guro Hospital in Seoul, Korea were included. All patients underwent comprehensive neuropsychological tests and completed the Non-Motor Symptoms Scale (NMSS). The frequency and severity of constipation were assessed using the NMSS GI symptoms scale, we used logistic regression analysis and partial correlation analysis to determine the associations between constipation score, MCI, and each neuropsychological dysfunction.Results Frequent and severe constipation was associated with MCI in patients with PD at diagnosis regardless of disease severity. Specifically, constipation was related to poor performance in frontal-executive and visuospatial functions after controlling for age and sex.Conclusion Our findings may provide an understanding of constipation as a marker associated with cognitive impairment in individuals with PD. Therefore, the evaluation of cognitive function is warranted in PD patients with constipation, while further studies are necessary to investigate the detailed mechanism of our results. |
| Databáze: | OpenAIRE |
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