1,25-Dihydroxyvitamin D3 induces in vivo the decidualization of rat endometrial cells
| Autor: | G M Acker, M Garabédian, A Halhali |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Embryology
medicine.medical_specialty Uterus Biology Endometrium Endocrinology Calcitriol In vivo Internal medicine Decidua medicine Animals Decidual cells Pseudopregnancy Calcifediol Obstetrics and Gynecology Decidualization Rats Inbred Strains Organ Size Cell Biology Decidual reaction Rats medicine.anatomical_structure Reproductive Medicine In utero Gestation Female |
| Zdroj: | Reproduction. 91:59-64 |
| ISSN: | 1741-7899 1470-1626 |
| Popis: | Intraluminal injection of female rats at Day 5 of pseudopregnancy with 10-500 ng 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) significantly increased the uterine weight and induced decidual reaction. This effect was observed as early as the 3rd day after 1,25-(OH)2D3 injection. It was detectable only in the injected left horn and not in the non-injected right horn. A 500 ng dose of 25-(OH)D3 had no such effect. The present in-vivo results suggest that 1,25-(OH)2D3 may play a physiological role in endometrial cell differentiation into decidual cells, a crucial step in the process of blastocyst implantation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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