mTOR Signaling at the Crossroad between Metazoan Regeneration and Human Diseases
| Autor: | Patrick Cormier, Julia Morales, Agnès Boutet, Yasmine Lund-Ricard |
|---|---|
| Přispěvatelé: | Laboratoire de Biologie Intégrative des Modèles Marins (LBI2M), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Station biologique de Roscoff (SBR), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
human diseases
muscle [SDV]Life Sciences [q-bio] Review lcsh:Chemistry 0302 clinical medicine Osteogenesis Intestinal Mucosa Axon lcsh:QH301-705.5 Spectroscopy axon 0303 health sciences Kinase Stem Cells TOR Serine-Threonine Kinases Cell Differentiation General Medicine differentiation Medical research 3. Good health Computer Science Applications Cell biology medicine.anatomical_structure mTOR pathway Disease Susceptibility Stem cell Signal Transduction kidney autophagy proliferation appendage Biology liver Catalysis Inorganic Chemistry 03 medical and health sciences epidermis medicine Animals Humans Physical and Theoretical Chemistry Muscle Skeletal Molecular Biology PI3K/AKT/mTOR pathway 030304 developmental biology Wound Healing Mtor signaling Regeneration (biology) Organic Chemistry Autophagy Axons stem cell whole-body lcsh:Biology (General) lcsh:QD1-999 regeneration Hepatocytes 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 2718, p 2718 (2020) International Journal of Molecular Sciences International Journal of Molecular Sciences, MDPI, 2020, 21 (8), pp.2718. ⟨10.3390/ijms21082718⟩ |
| ISSN: | 1661-6596 1422-0067 |
| Popis: | International audience; A major challenge in medical research resides in controlling the molecular processes of tissue regeneration, as organ and structure damage are central to several human diseases. A survey of the literature reveals that mTOR (mechanistic/mammalian target of rapamycin) is involved in a wide range of regeneration mechanisms in the animal kingdom. More particularly, cellular processes such as growth, proliferation, and differentiation are controlled by mTOR. In addition, autophagy, stem cell maintenance or the newly described intermediate quiescence state, G alert , imply upstream monitoring by the mTOR pathway. In this review, we report the role of mTOR signaling in reparative regenerations in different tissues and body parts (e.g., axon, skeletal muscle, liver, epithelia, appendages, kidney, and whole-body), and highlight how the mTOR kinase can be viewed as a therapeutic target to boost organ repair. Studies in this area have focused on modulating the mTOR pathway in various animal models to elucidate its contribution to regeneration. The diversity of metazoan species used to identify the implication of this pathway might then serve applied medicine (in better understanding what is required for efficient treatments in human diseases) but also evolutionary biology. Indeed, species-specific differences in mTOR modulation can contain the keys to appreciate why certain regeneration processes have been lost or conserved in the animal kingdom. |
| Databáze: | OpenAIRE |
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