Phenolic profile by HPLC-ESI-MS/MS and enzymatic inhibitory effect of Bryophyllum delagoense
Autor: | Michele Debiasi Alberton, Gustavo Amadeu Micke, Jéssica Lopes, Milena Paim, Edenize Maria Katrucha, Diogo Alexandre Siebert, Adrielli Tenfen, Luciano Vitali, Júlia Candiani dos Santos |
---|---|
Rok vydání: | 2022 |
Předmět: |
Folk medicine
chemistry.chemical_classification biology Traditional medicine 010405 organic chemistry Chemistry Organic Chemistry Hplc esi ms ms Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Enzyme Bryophyllum Cactus Bryophyllum delagoense Inhibitory effect |
DOI: | 10.6084/m9.figshare.11968233 |
Popis: | Bryophyllum delagoense (Eckl. & Zeyh.) Druce, native to Madagascar, is popularly known as “abyssian cactus” and popularly used in folk medicine as an analgesic and healing agent. The study methodology was divided into the phytochemical study: fractionation and identification of phenolic compounds by HLPC-ESI-MS/MS from the methanolic extract (ME), and fractions (DCMF and EAF) of leaves of B. delagoense, and biological activity with acetylcholinesterase and α-glucosidase inhibition of extracts and fractions by in vitro enzymatic techniques. Twenty-seven phenolic compounds were identified, being the highest concentration of syringic acid (87.848 mg g−1). The DCMF fraction showed the best biological activity for inhibition of α-glucosidase enzyme (0.125 mg mL−1). |
Databáze: | OpenAIRE |
Externí odkaz: |