Prevention of Population Shifts in Oral Microbial Communities in vitro by Low Fluoride Concentrations
| Autor: | David J. Bradshaw, Philip Marsh, Ailsa S. McKee |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
0301 basic medicine
Population Colony Count Microbial Microbial metabolism Microbial Sensitivity Tests Carbohydrate metabolism Dental plaque Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Sodium fluoride medicine Humans Food science education General Dentistry Mouth education.field_of_study Bacteria 030206 dentistry Metabolism Hydrogen-Ion Concentration medicine.disease stomatognathic diseases Glucose 030104 developmental biology chemistry Microbial population biology Fermentation Sodium Fluoride Fluoride |
| Zdroj: | Journal of Dental Research. 69:436-441 |
| ISSN: | 1544-0591 0022-0345 |
| Popis: | A continuous culture system has been used to study the effects of low (sub-MIC) levels of sodium fluoride on the stability and metabolism of a defined oral microbial community. The microflora was also subjected to glucose pulses at pH 7.0, with and without subsequent pH control. At pH 7.0, a continuous supply of 1 mmol/L NaF reduced slightly the viable counts of the oral microflora, although their proportions were relatively unaffected. At pH 7.0, during glucose pulsing, 1 mmol/L NaF prevented the rise in proportions of A. viscosus and reduced the levels of B. intermedius. Glucose pulsing without pH control and in the absence of fluoride markedly inhibited the growth of many species, and L. casei, V. dispar, and S. mutans predominated in the culture. Fluoride (1 mmol/L), either pulsed with the glucose or provided continuously, reduced both the rate of change and the degree of fall in pH, and in doing so prevented the enrichment of S. mutans in the culture. Fluoride also reduced the pH-mediated inhibition of other members of the oral community, although S. sanguis was inhibited even further. Thus, even sub-MIC levels of fluoride may have a beneficial anti-bacterial effect on dental plaque by interfering with acid production. This would reduce the pH-mediated disruption to the balance of the microflora and suppress the selection of S. mutans. |
| Databáze: | OpenAIRE |
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