Long range restriction map of the von Hippel-Lindau gene region on human chromosome 3p
| Autor: | Holger Hummerich, Susanne C. Szymanski, Elisabeth Schröder, Michael I. Lerman, G. Röhrborn, Farida Latif |
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| Rok vydání: | 1993 |
| Předmět: |
von Hippel-Lindau Disease
Genetic Linkage Centromere Restriction Mapping Biology urologic and male genital diseases Restriction map Gene mapping Genetic linkage Genetics Tumor Cells Cultured Humans Genes Tumor Suppressor Gene Carcinoma Renal Cell Genetics (clinical) Chromosome Telomere Kidney Neoplasms Electrophoresis Gel Pulsed-Field Gene Expression Regulation Neoplastic Chromosome 3 CpG site Chromosomes Human Pair 3 Dinucleoside Phosphates |
| Zdroj: | Human genetics. 92(3) |
| ISSN: | 0340-6717 |
| Popis: | Von Hippel-Lindau disease is a heritable tumour syndrome caused by the loss of the function of a tumour suppressor gene on the short arm of human chromosome 3. The interval RAF1-D3S18 (3p25–3p26) has been identfied by genetic linkage studies to harbour the von Hippel-Lindau gene. We have constructed a long range restriction map of this region and have succeeded in demonstrating the physical linkage of loci D3S726 (DNA probe LIB31-38), D3S18 (c-LIB-1, L162E5), D3S601 (LIB1963) and D3S587 (LIB 12–48). Since multipoint analysis has located D3S601 proximal to D3S726, the physical map should be oriented with D3S726 towards the telomere. The order and distances of probes within the von Hippel-Lindau gene region is as follows: telomere — LIB3138 — ( |
| Databáze: | OpenAIRE |
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