Increased blood pressure visit-to-visit variability in patients with systemic lupus erythematosus: association with inflammation and comorbidity burden
| Autor: | Jocelyn S. Gandelman, Cecilia P. Chung, Alyson L Dickson, T Reese, April Barnado, Omair A. Khan, Jacquelyn E. Neal, Megan M. Shuey, Katherine A. Barker, Charles M. Stein, William D. Dupont |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Databases Factual viruses Population Blood Pressure Inflammation Comorbidity Severity of Illness Index Article Rheumatology Adrenal Cortex Hormones Risk Factors Internal medicine medicine Humans Lupus Erythematosus Systemic In patient Risk factor education Cyclophosphamide education.field_of_study business.industry biochemical phenomena metabolism and nutrition Middle Aged Mycophenolic Acid medicine.disease Logistic Models Blood pressure Case-Control Studies Hypertension Multivariate Analysis Female medicine.symptom business Hydroxychloroquine |
| Zdroj: | Lupus |
| ISSN: | 1477-0962 0961-2033 |
| Popis: | Background Blood pressure visit-to-visit variability is a novel risk factor for deleterious long-term cardiac and renal outcomes in the general population. We hypothesized that patients with systemic lupus erythematosus (SLE) have greater blood pressure visit-to-visit variability than control subjects and that blood pressure visit-to-visit variability is associated with a higher comorbidity burden. Methods We studied 899 patients with SLE and 4172 matched controls using de-identified electronic health records from an academic medical center. We compared blood pressure visit-to-visit variability measures in patients with SLE and control subjects and examined the association between blood pressure visit-to-visit variability and patients’ characteristics. Results Patients with SLE had higher systolic blood pressure visit-to-visit variability 9.7% (7.8–11.8%) than the control group 9.2% (7.4–11.2%), P Conclusion Patients with SLE had higher blood pressure visit-to-visit variability than controls, and this increased blood pressure visit-to-visit variability was associated with greater Charlson comorbidity scores, several clinical characteristics and immunosuppressant medications. In particular, hydroxychloroquine prescription was associated with lower blood pressure visit-to-visit variability. |
| Databáze: | OpenAIRE |
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