Bioactive compounds fromRhodiola rosea (Crassulaceae)
| Autor: | G.H.Neil Towers, Emma S. Tomlinson Guns, Selvarani Vimalanathan, Sherwin Xie, Andy Eberding, Brian J. Hillhouse, Dong Sheng Ming |
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| Rok vydání: | 2005 |
| Předmět: |
Staphylococcus aureus
Microbial Sensitivity Tests Pharmacognosy medicine.disease_cause Plant Roots law.invention Inhibitory Concentration 50 chemistry.chemical_compound law Cell Line Tumor Rhodiola medicine Humans Gallic acid Antibacterial agent Pharmacology Plant Stems biology Traditional medicine Plant Extracts biology.organism_classification Antineoplastic Agents Phytogenic Anti-Bacterial Agents Crassulaceae Rhodiola rosea chemistry Phytotherapy |
| Zdroj: | Phytotherapy Research. 19:740-743 |
| ISSN: | 1099-1573 0951-418X |
| Popis: | The methanol extract of the underground part of Rhodiola rosea was found to show inhibitory activity against Staphylococcus aureus. Bioactivity-guided fractionation of a 95% ethanol extract from the stems of R. rosea led to the isolation of five compounds: gossypetin-7-O-L-rhamnopyranoside (1), rhodioflavonoside (2), gallic acid (3), trans-p-hydroxycinnamic acid (4) and p-tyrosol (5). Their structures were elucidated by UV, IR, MS and NMR data, as well as by comparison with those of the literature. Compounds 1 and 2 were evaluated for their antibacterial and antiprostate cancer cell activities. Compounds 1 and 2 exhibited activity against Staphylococcus aureus with minimum inhibitory concentrations of 50 microg/mL and 100 microg/mL, respectively. Cytotoxicity studies of 1 and 2 also displayed activity against the prostate cancer cell line with IC(50) values of 50 microg/mL and 80 microg/mL, respectively. |
| Databáze: | OpenAIRE |
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