Cerebrospinal fluid and plasma monoamines and their metabolites in euthymic bipolar patients
| Autor: | Wade H. Berrettini, John I. Nurnberger, Markku Linnoila, Timo Seppälä, Mika Scheinin, Susan Simmons-Alling, William Narrow, Elliot S. Gershon |
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| Rok vydání: | 1985 |
| Předmět: |
Neurotransmitter Agents
medicine.medical_specialty Bipolar Disorder Lithium (medication) business.industry Dopamine Dopaminergic Homovanillic Acid Hydroxyindoleacetic Acid Lithium Serotonergic Methoxyhydroxyphenylglycol Norepinephrine Normal volunteers Endocrinology Monoamine neurotransmitter Cerebrospinal fluid Group differences Internal medicine 3 4-Dihydroxyphenylacetic Acid Humans Medicine business Biological Psychiatry medicine.drug |
| Zdroj: | Biological Psychiatry. 20:257-269 |
| ISSN: | 0006-3223 |
| DOI: | 10.1016/0006-3223(85)90055-1 |
| Popis: | In a search for trait markers in manic-depressive illness, we studied cerebrospinal fluid (CSF) and plasma monoamines and their metabolites in 25 lithium-treated euthymic bipolar patients (12 of whom provided unmedicated samples) and 30 normal volunteers. No group differences were found. Lithium treatment showed a trend to increase CSF hydroxy-indoleacetic acid (HIAA) (p = 0.05). Dopaminergic and serotonergic metabolites were highly correlated in the CSF of all three groups. We found no evidence of a trait marker for manic-depressive illness among CSF monoamines and their metabolites. |
| Databáze: | OpenAIRE |
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