The Extension of the German CERAD Neuropsychological Assessment Battery with Tests Assessing Subcortical, Executive and Frontal Functions Improves Accuracy in Dementia Diagnosis
| Autor: | Manfred Berres, Nicole Schmid, Michael M. Ehrensperger, Andreas U. Monsch, Irene R. Beck |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Aging
medicine.medical_specialty Cognitive Neuroscience media_common.quotation_subject Disease lcsh:Geriatrics Audiology Logistic regression Vascular dementia lcsh:RC346-429 Neglect 03 medical and health sciences 0302 clinical medicine mental disorders medicine Dementia Original Research Article Neuropsychological assessment Psychiatry lcsh:Neurology. Diseases of the nervous system 030304 developmental biology media_common 0303 health sciences medicine.diagnostic_test Cognition Alzheimer's disease medicine.disease 3. Good health lcsh:RC952-954.6 Diagnostic equipment Psychiatry and Mental health Neuropsychological tests Alzheimer’s disease Psychology Frontotemporal dementia 030217 neurology & neurosurgery |
| Zdroj: | Dementia and Geriatric Cognitive Disorders EXTRA Dementia and Geriatric Cognitive Disorders Extra, Vol 4, Iss 2, Pp 322-334 (2014) |
| ISSN: | 1664-5464 |
| DOI: | 10.1159/000357774 |
| Popis: | Background/Aims: Alzheimer's disease (AD) is the most common form of dementia. Neuropsychological assessment of individuals with AD primarily focuses on tests of cortical functioning. However, in clinical practice, the underlying pathologies of dementia are unknown, and a focus on cortical functioning may neglect other domains of cognition, including subcortical and executive functioning. The current study aimed to improve the diagnostic discrimination ability of the Consortium to Establish a Registry for Alzheimer's Disease - Neuropsychological Assessment Battery (CERAD-NAB) by adding three tests of executive functioning and mental speed (Trail Making Tests A and B, S-Words). Methods: Logistic regression analyses of 594 normal controls (NC), 326 patients with mild AD and 224 patients with other types of dementia (OD) were carried out, and the area under the curve values were compared to those of CERAD-NAB alone. Results: All comparisons except AD-OD (65.5%) showed excellent classification rates (NC-AD: 92.7%; NC-OD: 89.0%; NC-all patients: 91.0%) and a superior diagnostic accuracy of the extended version. Conclusion: Our findings suggest that these three tests provide a sensible addition to the CERAD-NAB and can improve neuropsychological diagnosis of dementia. |
| Databáze: | OpenAIRE |
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