Comparison of acid and water-soluble chitosan doped fibrous cellulose hemostat wet laid nonwoven web for hemorrhage application
| Autor: | M. Abinaya, N. Vikash, P. Brindha, V. R. Giri Dev, T. Hemamalini |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Hemorrhage
macromolecular substances 02 engineering and technology Absorption (skin) Biochemistry Hemostatics Chitosan 03 medical and health sciences chemistry.chemical_compound Structural Biology Coagulation (water treatment) Humans Cellulose Molecular Biology 030304 developmental biology Whole blood Hemostat 0303 health sciences Chromatography technology industry and agriculture Water General Medicine Adhesion equipment and supplies 021001 nanoscience & nanotechnology carbohydrates (lipids) chemistry 0210 nano-technology Citric acid |
| Zdroj: | International journal of biological macromolecules. 147 |
| ISSN: | 1879-0003 |
| Popis: | Fibrous hemostat was produced using wet laying technique comprising of acid and water soluble chitosan with fibrous cellulose. The hemostatic efficiency and their structural properties were evaluated using blood clotting time, whole blood adhesion and analytical characterization techniques. The maximum concentration of chitosan utilised for the production of nonwoven was 1.5 w/v % upon which increased the viscosity of the solution. The absorption of phosphate buffer solution was found to be 1117% for acid soluble chitosan based nonwoven whereas for water soluble chitosan based nonwoven was 997%. Increased red blood cells and platelets were found to be higher in acid soluble chitosan compared to water soluble chitosan based cellulose nonwoven. The blood clotting time for acid soluble chitosan nonwoven was found to be 166 s and water soluble chitosan nonwoven was 170 s. The developed hemostat have potential application in reducing blood loss and also inducing the blood coagulation pathway which was confirmed by the adhesion of platelets on to the surface of nonwoven web. |
| Databáze: | OpenAIRE |
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