Impact of acute and subchronic inhalation exposure to PbO nanoparticles on mice

Autor:	Pavel Mikuška, Ivan Míšek, Marcela Buchtová, Zuzana Nováková, Aleš Hampl, Jana Dumková, Z. Večeřa, Bohumil Dočekal, Jana Lebedová, Lucie Bláhová, Klára Hilscherová
Rok vydání:	2018
Předmět:	Male 010504 meteorology & atmospheric sciences Biomedical Engineering Nanoparticle 010501 environmental sciences Kidney Toxicology medicine.disease_cause 01 natural sciences Road transport Mice Administration Inhalation Tissue damage medicine Animals Tissue Distribution Lung 0105 earth and related environmental sciences Inhalation exposure Inhalation Exposure Chemistry Brain Oxides Glutathione 3. Good health Lead Liver Environmental chemistry Nanoparticles Lipid Peroxidation Oxidative stress
Zdroj:	Nanotoxicology. 12:290-304
ISSN:	1743-5404 1743-5390
DOI:	10.1080/17435390.2018.1438679
Popis:	Lead nanoparticles (NPs) are released into air from metal processing, road transport or combustion processes. Inhalation exposure is therefore very likely to occur. However, even though the effects of bulk lead are well known, there is limited knowledge regarding impact of Pb NPs inhalation. This study focused on acute and subchronic exposures to lead oxide nanoparticles (PbO NPs). Mice were exposed to PbO NPs in whole body inhalation chambers for 4-72 h in acute experiment (4.05 × 10
Databáze:	OpenAIRE
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