Study of Colombia North Wiwa El Encanto Amerindians HLA- genes: Pacific Islanders relatedness
| Autor: | Jose Palacio-Gruber, Adrian Lopez-Nares, Brayan Bayona, Jorge Nuñez, Ignacio Juarez, Manuel Martin-Villa, Ennio Hernández, Ester Muñiz, Cristina Campos, Antonio Arnaiz-Villena, Carlos Silvera |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Native Hawaiian or Other Pacific Islander Genotype Immunology Population Ethnic group Colombia Pacific Islands 03 medical and health sciences 0302 clinical medicine Gene Frequency HLA Antigens Ethnicity Immunology and Allergy Humans education Allele frequency Phylogeny education.field_of_study Histocompatibility Testing Indians South American Haplotype Linguistics General Medicine Transplantation 030104 developmental biology Geography Haplotypes Pacific islanders Ethnology 030215 immunology Histocompatibility gene |
| Zdroj: | Human immunology. 79(7) |
| ISSN: | 1879-1166 |
| Popis: | We have studied Wiwa/Sanja Amerindians HLA-A, -B, -C, -DRB1 and DQB1 allele frequencies and extended haplotypes in 52 unrelated individuals from “El Encanto” town at Guanachaca riverside. High frequency alleles were in general present in other Amerindian populations. Also, three extended haplotypes and eight ones were respectively both “new found” and already described in Amerindians from North, Central and South America, including Lakota-Sioux, Mayas, Teeneks, Quechua and Aymaras. Analyses of HLA-A*24:02 and -C*01:02 Wiwa high frequency alleles suggested a specific relatedness with another Amerindian and Pacific Islander ethnic groups (these two particular alleles bearing in high frequencies); they include New Zealand Maoris, Taiwanese, Japanese, Papua New Guinea, and Samoans among others. This may indicate that selective forces are maintaining these two alleles high frequency within this wide American/Pacific area. |
| Databáze: | OpenAIRE |
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