Microchimerism Evaluation in Recipients of Living-Related or Unrelated Deceased Allograft Renal Transplants
| Autor: | Janaina Cristiana de Oliveira Crispim, Eduardo Antônio Donadi, Isabela Jubé Wastowski, L. T.S. Saber, Roberto Silva Costa, L.P.C. Faggioni |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Urinary system Y chromosome Cadaver Living Donors medicine Humans Family Immunologic Tolerance DNA Primers Transplantation Chimera Transplantation Kidney Chromosomes Human Y Base Sequence business.industry Histocompatibility Testing Microchimerism Middle Aged Kidney Transplantation Tissue Donors medicine.anatomical_structure Testis determining factor Immunology Female Surgery Solid organ business |
| Zdroj: | Transplantation Proceedings. 38:2828-2830 |
| ISSN: | 0041-1345 |
| Popis: | The presence of microchimerism in the peripheral blood of solid organ graft recipients has been associated with long-term solid organ acceptance, immunologic tolerance, and less aggressive immunosuppressive therapy. Molecular biology assays are among the most sensitive methods to detect microchimerism, primarily to evaluate Y chromosome sequences in females as indirect evidence of circulating male nucleated donor cells. We screened for the presence of the SRY sequence region in peripheral blood of 13 female recipients of male kidney grafts: 5 living-related and 8 deceased grafts. 2 Only patients who received grafts from related living donors exhibited microchimerism. Five of 13 patients studied exhibited better graft outcomes, including the 4 who were positive for the SRY sequences. |
| Databáze: | OpenAIRE |
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