METHADONE-INDUCED QTC PROLONGATION IS ASSOCIATED WITH CYP2C19 GENOTYPE AND WITH PLASMA ETHYLIDENE-1,5-DIMETHYL-3,3-DIPHENYLPYRROLIDENE (EDDP) CONCENTRATION: A POSSIBLE MECHANISTIC LINK

Autor: Eric Johnson, Stacey Knight, Jeffrey Rollo, Dawn Niemann, Mark Morgan, David Moody, Jeffrey L. Anderson, John A. Huntinghouse, Wenfang B. Fang, Joseph B. Muhlestein, John F. Carlquist, Marian Jacobsen
Rok vydání: 2014
Předmět:
Zdroj: Journal of the American College of Cardiology. 63(12)
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(14)60445-9
Popis: Methadone-associated sudden arrhythmic death is due to polymorphic ventricular fibrillation arising from QT prolongation associated with perturbations in the delayed potassium rectifier current. Risk for QT prolongation has been independently associated with both increased formation of the methadone
Databáze: OpenAIRE